عنوان مقاله [English]
Background and objective: Study findings have suggested an association between dementia risk and
less intakes of Bvitamins and have speculated about their use as preventive agents, So this study examine
dietary and supplemental intakes of vitaminB12 and folic acid in dementia patients in compare to healthy
Method: Data collected were from participants of the Iran Alzheimer Association, cross sectional study of
120 men and women 50 years and older who were residents of Tehran in 2013. Dietary data were collected
using food frequency and 24-hour recall questionnaires. Nutrient composition information was obtained
from standard nutrient databases like the Food Processor (Nutritionist IV) and the SPSS version 19.0 for
Windows software program, was used for all statistical analysis.
Results: In multivariable Analysis of Covariance (ANCOVA) models that controlled for the effects of
covariates, total folic acid (dietary and supplemental) and dietary folic acid and vitaminB12 intake of dementia
patients were less. There were observed differences in risk of dementia by decreasing of total intake of folic
acid and vitamin B12.
Conclusion: Lower folic acid and vitaminB12 status were associated with risk of dementia, maintaining
levels through the consumption of specific foods and supplements is a viable option for dementia patients
and high risk people. Further studies examining associations between dietary intakes of B-vitamins,
biomarkers of B-vitamin status and cognitive endpoints are warranted.