بررسی تاثیر شنیدن آوای قرآن کریم بر آرامبخشی و سرعت القاء بیهوشی در بیماران کاندیدای بیهوشی عمومی براساس پایش پردازش شده نوار مغزBIS

Background & Objectives: Good preoperative sedation and anxiolysis helps in smooth induction and
optimal depth of anesthesia during induction, also laryngoscopy & tracheal intubation will be caused to
less hemodynamic perturbation. The objective of this study is determining the effect of listening to holy
Quran-e- karim tape before anesthesia on the degree of sedation and speed of induction and also variation
of hemodynamic variables during that time.
Methods & Materials: In a prospective single blind randomized clinical trial, 60 patients with ASA
physical class I & II, candidate for intra abdominal operation under general anesthesia was included. After
selection of the patients on the basis of inclusion and exclusion criteria’s, patients divided randomly in two
groups (case & control). Before giving any drugs, in the case group 10 min of holy Quran -e-karim reading
was played via a head phone. But in the second group head phone in the off position was applied. BIS
and heart rate was recorded before and after this 10 min in two groups. After that in the same time with
premedication injection (Fentanyl & Midazolam) another 3 min record of holy Quran-e-Karim was played to
group one patients, and again BIS was road. Hence induction of anesthesia was done with thiopental 5mg/
kg and Atracurium 0.5mg/kg. Time to reaching the BIS number to 50 in two groups was noted. Also BIS and
HR recorded at laryngoscopy and after intubation and 2 min later. Data was analyzed with SPSS statistical
software version 11. And P-value less than 0.05 considered valuable.
Results: Comparison of initial BIS & HR (after 10 min listening to tape) t-student test showed a meaningful
difference between two group (P-value = 0.05). That means the patients in case group had a better sedation
than other group. But analysis of data for other times didn’t show a significant difference between groups.
Discussion & conclusion: Results confirmed that, listening of holy Quran without giving any sedative
and analgesic drugs can reduce the BIS number from awareness level to the level of conscious sedation
(80<BIS<100). The aim of conscious sedation with this way is relieving patient’s anxiety and stress in a
safe manner and converting the patient’s stressful and intolerable preoperative condition to a tolerable one.